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drug-coated balloon 1

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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery disease: the importance of proper lesion preparation

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 75-84 doi: 10.1007/s11684-022-0950-1

Abstract: This retrospective single-center registry study included all consecutive patients who underwent percutaneous coronary intervention (PCI) for a de novo left main coronary artery lesion using drug coated-balloon (DCB)-only strategy between August 2011 and December 2018. To best of our knowledge, no previous studies of DCB-only strategy of treating de novo left main coronary artery disease, exist. The primary endpoint was major adverse cardiovascular events (MACEs) including cardiac death, non-fatal myocardial infarction, and target lesion revascularization (TLR). The cohort was divided into two groups depending on weather the lesion preparation was done according to the international consensus group guidelines. Sixty-six patients (mean age 75±8.6, 72% male), 52% of whom had acute coronary syndrome, underwent left main PCI with the DCB-only strategy. No procedural mortality and no acute closures of the treated left main occurred. At 12 months, MACE and TLR occurred in 24% and 6% of the whole cohort, respectively. If the lesion preparation was done according to the guidelines, the MACE and TLR rates were 21.2% and 1.9%. Left main PCI with the DCB only-strategy is safe leading to acceptable MACE and low TLR rates at one year, if the lesion preparation is done according to the guidelines.

Keywords： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary    

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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery disease: the importance of proper lesion preparation

Journal Article